Publications

Public releases

Awards

  • Alexandra Arranja (ChemE, CNRS) received a prize for her PhD Thesis “Development of copolymer nano-carriers for imaging and therapy” selected by the “Association des Universités de I’Académie de Strasbourg” where last November she defended her thesis. This award has also a financial compensation. The thesis was co-promoted in partnership between François Schosseler (CNRS) and Eduardo Mendes (ChemE).
  • Oleksandra Ivashchenko (MILabs, TU Delft) has been chosen by the Society of Nuclear Medicine and Molecular Imaging to be the recipient of the Alavi-Mandell Award for her publication entitled, “Ultra-High-Sensitivity Submillimeter Mouse SPECT”. The award is accompanied by a monetary reward.
  • Oleksandra Ivashchenko (MILabs, TU Delft) Marie Curie Alumni Association (MCAA) Micro Media Grant 2017

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PhD Theses

Publications 2017

  • Jennings, Laurence, Gilles Waton, François Schosseler and Eduardo Mendes, Towards a rational morphology control of frozen copolymer aggregates, Soft Matter, 2017, 10 p., DOI: 10.1039/C7SM01086A

Publications 2016

  • Arranja, A.,Tuning cellular interactions by varying the properties of polymeric nanocarriers: Composition and stabilization, Oral presentation, Dutch Polymer Days 2016, Lunteren, The Netherlands, 7-8 March 2016
  • Arranja, A., A. Schroder, M. Schmutz, G. Waton, F. Schosseler and E. Mendes, Cytotoxicity and internalization of Pluronic micelles stabilized by core cross-linking, Journal of Controlled Release, 2014, 196: 87-95, DOI: 10.1016/j.jconrel.2014.10.001
  • Arranja, A., G. Waton, F. Schosseler and E. Mendes, Lack of a unique kinetic pathway in the growth and decay of Pluronic micelles, Soft Matter, 2016, 12: 769-778, DOI: 10.1039/C5SM02353J
  • Arranja, A., A. Denkova, K. Morawska, G. Waton, S. van Vlierberghe, P. Dubruel, F. Schosseler and E. Mendes, Interactions of Pluronic nanocarriers with 2D and 3D cell cultures: Effects of PEO block length and aggregation state, Journal of Controlled Release, 2016, 224: 126-135, DOI: 10.1016/j.jconrel.2016.01.014
  • Arranja, A., O. Ivashchenko, A. Denkova, K. Morawska, G. Waton, S. van Vlierberghe, P. Dubruel, G. Waton, F. Beekman, F. Schosseler and E. Mendes, SPECT/CT imaging of Pluronic nanocarriers with varying PEO block length and aggregation state, Molecular Pharmaceutics, 2016, 13(3):1158–1165, DOI: 10.1021/acs.molpharmaceut.5b00958
  • De la Fuente A, Radchenko R, Tsotakos T, Tsoukalas C, Paravatou-PetsotasM, Harris AL, Köster U, Rösch F, Bouziotis P.Conjugation, labelling and in vitro/in vivo assessment of an anti-VEGF monoclonal antibody labelled with niobium isotopes. Paper submitted to Radiochim Acta.
  • De la Fuente A, Eppard E, Mohr N, Allmeroth M, Pektor S, Miderer M, Zentel R, Rösch F. Labeling of HPMA-based polymer-conjugates with metallic radionuclides for theranostic applications. In preparation.
  • De la Fuente A, Kramer S, Mohr N, Pektor S, Bausbacher N, Miederer M,ZentelR, Rösch F.68Ga-,111In-oxine: A novel strategy of in situ radiolabelling of HPMA-based micelles. In preparation.
  • Eppard E, de la Fuente A, Benesova M, Kopka K, Essler E, Roesch F. Synthesis, in vitro evaluation and first human useof44Sc-PSMA-617 for PET imaging of prostate cancer. In preparation.
  • Jennings, L., O. Ivashchenko, I. J. C. Marsman, A. C. Laan, A. G. Denkova, G. Waton, F. J. Beekman, F. Schosseler and E. Mende, In vivo biodistribution of stable spherical and filamentous micelles probed by high-sensitivity SPECT, Biomater. Sci. 2016, 4(8):1202-1211. DOI: 10.1039/c6bm00297h
  • Jennings, L., P. Glazer, A. C. Laan, R. M. de Kruijff, G. Waton, F. Schosseler and E. Mendes, The role of confinement and corona crystallinity on the bending modulus of copolymer micelles measured directly by AFM flexural tests, Paper, Soft Matter RSC, Strasbourg, France, Soft Matter, 2016, 12, 7324-7329, DOI: 10.1039/c6sm00983b
  • Radchenko, V., Bouziotis, P., Tsotakos, T., Paravatou-Petsotas, M., De la Fuente, A., Loudos, G., Harris, A.L., Xanthopoulos S, Filosofov D, Hauser H, Eisenhut M, Ponsard B, Roesch F. Labeling and preliminary in vivo assessment of niobium-labeled radioactive species: A proof-of-concept study. Nucl Med Biol. 2016;43(5):280-7, DOI: 10.1016/j.nucmedbio.2016.02.003
  • Santini, Costanza, Alfred Morgenstern, Frank Bruchertseifer, Christos Apostolidis, Maria Rius Montraveta, Mirijam Weiss, Marion de Jong , Monique Bernsen, “Ac-225: benefits and challenges for in vivo application”, Oral presentation at NKRV, Delft, The Netherlands, 22 January 2016
  • Laan, Adrianus C, Costanza Santini,, Laurence Jennings, Marion de Jong, Monique Bernsen, Antonia G Denkova,“Radiolabeling polymeric micelles for in vivo evaluation: a novel, fast and facile method”, EJNMMI Research (2016) 6:12, DOI 10.1186/s13550-016-0167-x
  • Morawska, Karolina, Anna de la Fuente, Sandra Van Vlierberghe, Frank Roesch and Peter Dubruel, Towards efficient radionuclide delivery via modification of Pluronic copolymers, Poster presentation at ChemCYS 2016 conference, Blankenberge, Belgium, 16-18 March 2016
  • Santini, Costanza, Alexandra Arranja, Antonia Denkova, François Schosseler, Karolina Morawska, Peter Dubruel, Eduardo Mendes , Marion de Jong , Monique Bernsen, “Biodistribution of radiolabeled Pluronic P94 unimers in tumor bearing mice”, Oral presentation at ECR 2016, Vienna, Austria, 2-6 March 2016
  • Santini, C., J. Kuil, A. Bunschoten, S. Pool, E. De Blois, R. Ridwan, J. Essers, M.R. Bernsen, F.W.B. van Leeuwen, M. De Jong, Evaluation of a Fluorescent and Radiolabeled Hybrid Somatostatin Analogue In Vitro and in Mice Bearing H69 Neuroendocrine Xenografts, J Nucl Med 2016 57:1289-1295, DOI: 10.2967/jnumed.115.164970
  • Santini, Costanza, Adrianus C Laan, Marion de Jong , Antonia Denkova, Monique Bernsen,“PS-b-PEO polymeric micelles: dependence of biodistribution on micellar size and dose”, Poster presentation, at NKRV 2016, Nijmegen, The Netherlands, 1 July 2016
  • Santini, Costanza, Adrianus C Laan, Laurence Jennings, Marion de Jong , Antonia Denkova, Monique Bernsen, “PS-b-PEO polymeric micelles: dependence of biodistribution and tumor uptake on micellar dose and size”, Oral presentation at EANM 2016, Barcelona, Spain, 15-19 October 2016
  • Santini, Costanza, Adrianus C Laan, Laurence Jennings, Marion de Jong, Antonia G Denkova, Monique R Bernsen, Size and dose: factors influencing biodistribution and tumor uptake of polymeric micelles, Paper submitted to EJNMMI Research
  • Santini, C. A. Arranja, A. G. Denkova, F. Schosseler, K. Morawska, P. Dubruel, E. Mendes, M. de Jong, M. Bernsen, Injection route determines biodistribution and tumor accumulation of Pluronic block copolymers, Paper submitted to Journal of Controlled Release
  • Van der Have, F, O Ivashchenko, MC Goorden, Ramakers, RM, Beekman, FJ, High-resolution clustered-pinhole (131)Iodine SPECT imaging in mice, Nucl Med Biol. 2016; 43(8): 506-11., August 2016, DOI: 10.1016/j.nucmedbio.2016.05.015

Publications 2015

  • Arranja, A., F. Schosseler, G. Waton, E. Mendes, Stabilized Pluronic micelles for imaging and therapy: in vitro study, Poster Presentation, 4th International Conference on Multifunctional, Hybrid and Nanomaterials, 9-13 March 2015, Sitges, Spain
  • Arranja, A., A.G. Denkova, F. Schosseler, G. Waton, K. Morawska, S. van Vlierberghe, P. Dubruel, E. Mendes, Internalization of Molecular and Supramolecular Pluronic nanocarriers, Poster Presentation, 15th Conference on the International Association of Colloid and Interface Scientists, 24-29 May 2015, Mainz, Germany
  • Arranja, F. Schosseler, G. Waton, E. Mendes, Micellar growth and decay kinetics of Pluronic copolymers induced by temperature-steps, Poster Presentation, 15th Conference on the International Association of Colloid and Interface Scientists, 24-29 May 2015, Mainz, Germany
  • Arranja, A., Molecular and Supramolecular Pluronic nanocarriers for imaging and therapy: a two (2D) and three-dimensional (3D) in-vitro evaluation, Oral Presentation, Trace ‘n Treat Conference on Molecular and Supramolecular Carriers for Imaging and Therapy, 13-15 July 2015, Lisbon, Portugal
  • De la Fuente, A, Eppard, Elisabeth; Mohr, Nicole; Zentel, Rudolf; Roesch, Frank, Radiolabelling of polymeric nanocarriers with 68Ga and 44Sc and 89Zr as imaging agents for in vivo evaluations, European society of nuclar medicine,18-20 March 2015, Tübingen, Germany
  • De la Fuente, Ana; Mohr, Nicole; Zentel, Rudolf; Roesch, Frank, Novel strategy for radiolabelling polymeric micelles with a hydrophobic chelator for PET imaging, Poster presentation, Conference: Society of nuclear medicine and molecular imaging, 6-10 June 2015, Baltimore, USA
  • De la Fuente, A., V. Radchenko, P. Bouziotis, S. Xanthopoulos, U. Koester, F. Rösch, Conjugation, labelling and initial in vivo assessment of an anti-VEGF monoclonal antibody labelled with Niobium isotopes, Oral presentation, Trace ‘n Treat Conference on Molecular and supramolecular carriers for imaging and therapy, 13-15 July 2015, Lisbon, Portugal
  • De La Fuente, A. Eppard, E., Roesch, F., Essler, M., 44Sc labelling of DOTA-PSMA DKFZ-617 for dosimetry and therapy of prostate cáncer, Poster presentation, World Molecular Imaging Society Conference, 2-5 September 2015, Honolulu, USA
  • Garcia Cruz, V., New research in the 99Mo/99mTc generators, Oral presentation, 7th Int. Workshop on Coordination Chemistry of Metals with Medical Relevance and Supramolecular Buildings Blocks, June 2015, Berlin, Germany
  • Garcia Cruz, Vallin, Mesoporous Alumina oxide as a potential adsorbent for 99Mo/99mTc generators, Oral presentation, Trace ‘n Treat Conference on Molecular and supramolecular carriers for imaging and therapy, 13-15 July 2015, Lisbon, Portugal
  • O. Ivashchenko, F. van der Have, M.C. Goorden, R.M. Ramakers, F.J. Beekman. Ultra-high-sensitivity sub-mm mouse SPECT. J Nucl Med. 2015; 56(3): 470-475, March 2015, DOI 10.2967/jnumed.114.147140
  • Ivashchenko, O., F. van der Have, F.J. Beekman, Model-Based Depth-of-Interaction Compensation for Small-Animal Pinhole SPECT, Oral presentation, SNMMI 2015 annual meeting. J Nucl Med. vol 56: no. supplement 3, 44, 6-10 June, 2015, Baltimore, USA
  • Ivashchenko, O., L. Jennings, F. Schosseler, et al., High-sensitivity SPECT as a tool for pre-clinical evaluation of radiolabeled nanoparticles, Oral presentation, Trace ‘n Treat Conference on Molecular and Supramolecular Carriers for Imaging and Therapy, 13-15 July, 2015, Lisbon, Portugal
  • Jennings, L., G. Waton, F. Schosseler, E. Mendes, Spontaneous Emulsification and the morphology of kinetically frozen micelles,32nd Club Emulsion, 1-2 Octobre 2015, Pau, France
  • Morawska, Karolina, Sandra Van Vlierberghe, Peter Dubruel, Molecular carriers for radiolabelling, Poster presentation, Chemistry Open Day, UGhent, 10 May 2015, Ghent, Belgium
  • Morawska, Karolina, Alexandra Arranja, Sandra Van Vlierberghe, Gilles Waton, François Schosseler, Eduardo Mendes, Peter Dubruel, Preparation of stabilized micellar carriers based on Pluronic F127 for targeted drug delivery, Poster presentation, BPG conference, 18-19 May 2015, Houffalize, Belgium
  • Morawska, Karolina, Sandra Van Vlierberghe, Peter Dubruel, Pluronic based micelles as theranostic agents: modification and characterization, Oral presentation, Trace ‘n Treat Conference on Molecular and supramolecular carriers for imaging and therapy, 13-15 July 2015, Lisbon, Portugal
  • Morawska, Karolina, Anna de la Fuente, Sandra Van Vlierberghe, Frank Roesh, Peter Dubruel, Synthesis and characterization of poloxamer-based theranostic vehicles, Poster presentation, ESB conference, 31 Aug – 3 Sept 2015, Krakow, Poland
  • Postema, J.M. , L. Jennings, J. Bankstahl, G, Waton, F. Schosseler, E. Mendes, T.L. Ross, 18F-labeling and in vivo evaluation of PEG modified polystyrene micelles via PET imaging, Poster presentation, EANM ‘15,,10-14 Oct 2015, Hamburg, Germany
  • Postema, J.M., K. Morawska, J. Bankstahl, P. Dubruel, T.L. Ross, Direct 18F-labelling of macromolecular structures via strongly electron-deficient aromatic systems, Poster presentation, DGN, 22-25 April 2015, Hannover, Germany
  • Postema, J.M., J. Bankstahl, T.L. Ross,Direct 18F labelling of tosylated Pluronic® F127, Poster presentation, ISRS 2015, 26-31 May 2015, Columbia, MO, USA
  • Postema, J.M., L. Jennings, J. Bankstahl, G, Waton, F. Schosseler, E. Mendes, T.L. Ross,18F-labelling approaches for and in vivo evaluation of PEG modified polystyrene micelles, Oral presentation, Trace ‘n Treat Conference on Molecular and supramolecular carriers for imaging and therapy, 13-15 July 2015, Lisbon, Portugal
  • Santini, Costanza, Alexandra Arranja, Antonia Denkova, François Schosseler, Karolina Moraskwa , Sandra van Vlierberghe, Peter Dubruel, Eduardo Mendes, Monique Bernsen, Marion de Jong, Biodistribution of radiolabeled Pluronic P94 unimers in tumor bearing mice, Oral presentation, Trace ‘n Treat Conference on Molecular and supramolecular carriers for imaging and therapy , 13-15 July 2015, Lisbon, Portugal
  • Santini, Costanza, Alexandra Arranja, Laurence Jennings, Antonia Denkova, François Schosseler, Karolina Moraskwa, Sandra van Vlierberghe, Peter Dubruel, Eduardo Mendes, Monique Bernsen, Marion de Jong, “In vivo evaluation of radiolabeled block co-polymers”, Oral presentation at MiLabs User meeting, Utrecht, The Netherlands, 16 September 2015
  • Santini, Costanza, Alexandra Arranja, Antonia Denkova, François Schosseler, Karolina Morawska, Peter Dubruel, Eduardo Mendes , Marion de Jong , Monique Bernsen, “Effects of different injection routes in tumor accumulation and biodistribution of radiolabeled Pluronic P94 unimers”, Poster Presentation at EANM 2015, Hamburg, Germany, 10-14 October 2015
  • Santini, C. J. Kuil, A. Bunschoten, R. Ridwan, J. Essers, M.R. Bernsen, F.W.B. van Leeuwen, M. De Jong, A novel somatostatin-derived optical/nuclear probe: preclinical evaluation in vitro and in neuroendocrine tumour xenografts, Oral presentation, EANM 2014, 18-22 October 2015, Gothenburg, Sweden
  • van der Have F, Ivashchenko O, Goorden MC, Ramakers RM, Beekman FJ. High-resolution Iodine-131 SPECT imaging in Mice. IEEE Nuclear Science and Medical Imaging Conference, M3CP-77, 2015

Publications 2014

  • Arranja A., Schosseler F., Waton G. and Mendes E., Stabilized core cross-linked Pluronic micelles, Poster Presentation at the 4th International Colloids Conference, 15-18 June 2014, Madrid, Spain
  • Arranja, A. Schroder, M. Schumtz, G. Waton, F. Schosseler, E. Mendes, Cellular Internalization of stabilized Pluronic micelles, Poster Presentation, 3rd International Symposium in Applied Bioimaging, 16-17 October 2014, Porto, Portugal
  • Arranja, A., G. Waton, F. Schosseler, E. Mendes, Core Cross-linked Pluronic micelles: in vitro evaluation, Poster Presentation, Advanced Materials for Biomedical Applications (AMBA 2014), 18-21 November 2014, Ghent, Belgium
  • De la Fuente, A, Eppard, Elisabeth; Mohr, Nicole; Zentel, Rudolf; Roesch, Frank. Radiolabelling of polymeric nanocarriers with 68Ga and 44Sc and 89Zr as imaging agents for in vivo evaluations, European society of nuclar medicine, 3-4 Oct 2014, Istanbul, Turkey.
  • García Cruz V.,Vellieux S., Terpstra B.E., Oehlke E., Wolterbeek H.Th., Denkova A.G., Development of new sorbent materials for the preparation of 99Mo/99mTc generators, Oral presentation at RadChem 2014 “17th Radiochemical Conference”, 11-16 May 2014, Marianske Lazne
  • Hofmann, T., de la Fuente, A., Eppard, E., Roesch, F. Optimization of labelling PSMA-HBED with68Ga and its quality control systems. J Nucl Med 2014; 55 (supplement 1): 1009
  • Ivashchenko O., Van der Have F., Beekman F.J., Ultra-low-dose total body mouse SPECT with a focusing conical pinhole collimator, Oral presentation, SNMMI 2014 annual meeting, 7-11 June 2014, St. Louis, USA
  • Ivashchenko O., Van der Have F., Groen H., Villena J., Ramakers R., Weinans H., Beekman F.J., Quarter-mm molecular bone imaging with a stationary high-resolution SPECT system, Poster presentation, SNMMI 2014 annual meeting, 7-11 June 2014, St. Louis, USA
  • Ivashchenko, O., F. van der Have, J.L. Villena, H.C. Groen, R.M. Ramakers, H.H. Weinans, F.J. Beekman. Quarter-Millimeter-Resolution Molecular Mouse Imaging with U-SPECT+. Mol Imaging. 2014 Nov 1; 13(0):1-8, DOI: 10.2310/7290.2014.00053
  • Jennings L., Glazer P., Schosseler F., Mendes E., Novel and simplified approach towards three point, Poster presentation at the Dutch Polymer Days 2014, March 2014, Lunteren, the Netherlands
  • Jennings L., Laan A., Waton G., Schosseler F., Denkova A.G., Mendes E., In-vitro studies of fluorescent radio labeled micelles for targeted radionuclide therapy, Poster presentation European Symposium on Controlled Drug Delivery 2014, April 2014, Egmond aan Zee, The Netherlands
  • Jennings, L., O. Ivashchenko, I. J. C. Marsman, A. C. Laan, A. G. Denkova, G. Waton, F. J. Beekman, F. Schosseler, E. Mendes, In vivo Biodistribution of Stable Spherical and Filamentous Micelles Probed by High-sensitivity SPECT, Oral Presentation, 23th Int. Conf. Bioencapsulation, Delft, The Netherlands,2-4 September 2014
  • Morawska, D., Van Vlierberghe S., Samal S.K. and Dubruel P., Molecular carriers for radiotherapy, Poster presentation at Advanced Functional Polymer Materials conference, 26-28 May 2014, Liege, Belgium
  • Morawska, K., A. Arranja, S. van Vlierberghe, G. Waton, F. Schosseler, E. Mendes, P. Dubruel, Development of biocompatible multifunctional nanocarrriers for imaging and drug delivery application, Poster Presentation, Advanced Materials for Biomedical Applications (AMBA 2014), 18-21 November 2014, Ghent, Belgium
  • Santini, C., Kuil J., Pool S.E., Bunschoten A., Bernsen M., Van Leeuwen F.W.B., De Jong M., ‘SPECT/CT based evaluation of a hybrid Octreotate probe in the H69 neuroendocrine tumor model’, Abstract submitted to the European Congress of Radiology (ECR), 6-10 March 2014, Vienna, Austria
  • Santini C., Kuil J., Bunschoten A., Bernsen M.R., Van Leeuwen F.W.B., De Jong M., SPECT/CT based evaluation of a hybrid octreotate probe in the H69 neuroendocrine tumor model, Poster presentation at the NKRV meeting, 17 January 2014, Groningen, the Netherlands
  • Santini, Kuil J., Bunschoten A., Bernsen M.R., Van Leeuwen F.W.B., De Jong M., Multimodal optical-nuclear probe: first evaluation by SPECT/CT in a neuroendocrine tumor model, Poster presentation at the MolMed day, 20 February 2014, Rotterdam, the Netherlands
  • Stockhofe K., Postema J.M., Schieferstein H., Ross T.L., Radiolabeling of Nanoparticles and Polymers for PET Imaging, Review Article in Pharmaceuticals, 2 April 2014
  • Santini, C., J. Kuil, A. Bunschoten, M.R. Bernsen, F.W.B. van Leeuwen, M. De Jong,“Dual labelled octreotate for optical and nuclear imaging”,Oral presentation at COST meeting 2014, Istanbul, Turkey, 3-4 October 2014
  • van der Have F, Ivashchenko O, Groen HC, Ramakers RM, Durring H, Beekman FJ. Highresolution medium-sized animal multi-pinhole SPECT with stationary detectors. EANM Annual Meeting 2014, 18-22rd October 2014, Gothenburg, Sweden

Publications 2013

  • Arranja A., Waton G., Schosseler G., and Mendes E., ‘Growth and stability of PEO-PPO-PEO wormlike micelles’, Poster Presentation at the International Soft Matter Conference, 15-19 September 2013, Rome, Italy
  • De la Fuente A., Eppard E., Allmeroth M., Zentel R., and Roesch R., ‘Labeling of HPMA-based, functionalized polymer-systems using metallic radionuclides’, Poster presentation at the Cost action TD1004 Annual Meeting, 1-3 September 2013, Athens, Greece
  • Jennings L., ‘Measuring the elastic modulus of Polystyrene-b-Poly(Ethylene Oxide) wormlike micelles by three point bending tests’, Poster presentation at the Dutch Polymer Days 2013, 18-19 March 2013, Lunteren, The Netherlands
  • Jennings L., ‘Formation and characterization of ultra long polystyrene-b-poly(ethylene oxide)’, Poster presentation at the International Soft Matter Conference 2013, 15-19 September 2013, Rome, Italy
  • Morawska K., Van Vlierberghe S., Keshari Samal S. and Dubruel, P., ‘Molecular carriers for radiotherapy’, poster presented at the International Summer School Transferable Skills, 10-14 June 2013, Umeå, Sweden
  • Postema J. and Ross T.L., ‘New methods for direct and mild 18F-labeling of macromolecules’, Poster presentation at the Cost action TD1004 Annual Meeting, 1-3 September 2013, Athens, Greece
  • Ivashchenko O., van der Have F., Villena J., Beekman F.J., Quarter millimeter resolution pre-clinical SPECT with quarter-mm pinholes, EANM’13 – Annual Congress of the European Association of Nuclear Medicine, 19-23 October 2013, Lyon, France, P064

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